Only one or numerous drug overdose with oxycodone and acetaminophen can be a most likely lethal polydrug overdose, and session with a regional poison Handle Middle is suggested.
PERCOCET tablets can be a Plan II controlled material. Oxycodone is a mu-agonist opioid using an abuse liability much like morphine. Oxycodone, like morphine together with other opioids Employed in analgesia, might be abused and is also topic to criminal diversion.
Opioids can cross the placental barrier and possess the possible to cause neonatal respiratory despair. Opioid use for the duration of pregnancy might lead to a bodily drug-dependent fetus. Immediately after beginning, the neonate may well undergo significant withdrawal signs.
Opioid analgesics really should be utilised with warning when coupled with CNS depressant drugs, and should be reserved for conditions where the advantages of opioid analgesia outweigh the acknowledged pitfalls of respiratory despair, altered psychological point out, and postural hypotension.
The respiratory depressant effects of opioids include things like carbon dioxide retention and secondary elevation of cerebrospinal fluid tension, and will be markedly exaggerated in the presence of head personal injury, other intracranial lesions or a pre-existing boost in intracranial tension.
PERCOCET tablets may well obscure the analysis or scientific course in individuals with acute abdominal situations. Oxycodone may possibly aggravate convulsions in sufferers with convulsive read more Diseases, and all opioids might induce or aggravate seizures in some scientific options.
Oxycodone generates respiratory depression through direct action at respiratory facilities inside the brain stem and depresses the cough reflex by immediate impact on the center with the medulla.
Animal studies To guage the carcinogenic possible of oxycodone and acetaminophen haven't been carried out.
Lamotrigine: Serum lamotrigine concentrations could be lessened, creating a get more info lower in therapeutic consequences.
Oxycodone is often abused within a manner comparable to other opioid agonists, authorized or illicit. This could be regarded as when prescribing or dispensing PERCOCET tablets here in cases where the medical doctor or pharmacist is worried about an elevated threat of misuse, abuse, or diversion. Fears about misuse, addiction, and diversion shouldn't reduce the correct more info administration of pain.
Circumstances OF USE: The knowledge in this database is intended to health supplement, not substitute for, the experience and judgment of healthcare gurus. The knowledge is just not meant to go over all possible utilizes, Instructions, safety measures, drug interactions or adverse outcomes, nor must it's construed to point that usage of a particular drug is safe, appropriate or effective to suit your needs or any individual else.
A Health care Skilled needs to be consulted just before having any drug, transforming any diet regime or commencing or discontinuing any program of procedure.
Instruct patients to look for acetaminophen or APAP on offer labels and never to make use of more than one item which contains acetaminophen. Instruct sufferers to seek health-related attention promptly on ingestion of greater than 4000 milligrams of acetaminophen a day, even should they get more info truly feel well.
When PERCOCET tablets are no more desired, the unused tablets ought to be wrecked by flushing down the bathroom.